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Biological tissue substitutes: expanded polytetrafluoroethylene(ePTFE)

Time:2020/9/14 posted:Kehong Enterprises Co.,Ltd.

With the development of science and technology and the progress of the chemical synthesis industry, biological tissue substitutes suitable for the human body have become a reality. The progress of organizational substitutes will play a role in promoting development. In the 1970s, commonly used substitutes for biological tissues are: liquid silicone, ivory, dental materials, solid silicone, artificial bone materials and expanded polytetrafluoroethylene.

Liquid silica gel: Widely used in my country in the late 70s and early 80s, liquid silicone injection for rhinoplasty, clinical observations proved that after surgery, it can cause persistent erythema, swelling, skin necrosis of the nasal bridge, swelling of the teeth, and even facial disfigurement. . In addition, the liquid silica gel can diffuse, infiltrate and penetrate around, and it is difficult to handle without clear boundaries. The United States has strictly prohibited its use. Many domestic scholars advocate the prohibition or caution.

Ivory: It has good biocompatibility and generally does not cause rejection. However, it is gradually abandoned for rhinoplasty due to its hardness, difficulty in carving and shaping, and animal protection.

Dental materials: The dental materials used for rhinoplasty are polymethacrylic acid and methyl ester (PMMA), which are one of the solid biological tissue substitutes used for rhinoplasty earlier. It has good biocompatibility and needs to be blended when used for rhinoplasty, which is easily contaminated. In addition to incomplete contamination before surgery, it is easy to cause complications such as infection, pain and rejection. The preparation of the prosthesis is more complicated and the operation is relatively difficult, so it has been rarely used.

Solid silica gel: It is a commonly used rhinoplasty material at present, which is a polymer silicide. It has been used as early as 1972. After more than 20 years of observation, although its complication rate can reach 5%-20%, it is still the current clinical preferred due to its good biocompatibility and low price. One of rhinoplasty materials. Its main disadvantage is that it cannot establish blood circulation with the body and form a tissue connection. It is only surrounded by fibrous tissue, so the skin can be penetrated in the weak tissue. Due to the contracture of the fibrous capsule, it can cause the surface projection of the silicone prosthesis. , And affect the appearance effect.

Artificial bone material: mainly refers to hydroxyapatite. It is the main inorganic component of human bone tissue, so it has good biocompatibility, non-toxic, non-teratogenic, allergenic, carcinogenic and other side effects. It has been widely used in stomatology and orthopedics. Since the mid-1980s, it has been used for rhinoplasty and cosmetic surgery. Its operation is simple and easy to shape. Especially for those with low nose bridge, the postoperative effect is particularly satisfactory. Because it has no supporting effect, it is less effective for people with low nose tip.

Expanded polytetrafluoroethylene (ePTFE): From a medical point of view, it is an ideal substitute for biological tissues. Due to its good biocompatibility and unique microporous structure, it is non-toxic, non-carcinogenic, non-sensitizing and other side effects, and human tissue cells and blood vessels can grow into its micropores to form tissue connections, just like autologous tissue. The effect of rhinoplasty is very satisfactory. The ePTFE rhinoplasty material was introduced from the United States in 1995, but its high price has affected its general application. In short, the choice of rhinoplasty materials should be based on one's own conditions, economic conditions, and the doctor's diagnosis and prompts before making a decision.








膨体聚四氟乙烯(ePTFE):从医学角度,是目前理想的生物组织代用品。由于其良好的生物相容性及特有的微孔结构,无毒、无致癌、无致敏等副作用,而且人体组织细胞及血管可长入其微孔,形成组织连接,如同自体组织一样。用其隆鼻效果十分满意。ePTFE隆鼻材料于1995年从美国引进国内,但其价格昂贵,影响了其普遍应用。总之,隆鼻材料的选用,应根据自身条件、经济条件,结合医生的诊断及提示,方可做出决定。 (ePTFE):  (ePTFE):

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